Prognostic value of d dimer in ischemic stroke

Abstract

Background: Stroke is a major contributor to both disability and death worldwide. Meanwhile, the D-dimer blood test has become an increasingly valuable tool in diagnostic protocols for ruling out venous thromboembolism. This test detects the presence of D-dimer, a substance that forms during the breakdown of blood clots containing fibrin, making it a straightforward and effective means of screening for this condition. Numerous research studies have explored the relationship between plasma hemostatic markers and the outcomes of acute ischemic stroke (AIS). Within this area of investigation, one particular marker that has received a great deal of attention is D-dimer. This substance has emerged as a focal point of research into its potential role in AIS, with multiple studies examining its impact on this condition. Aim of stud: To evaluate the prognostic value of Ddimer in patients with ischemic stroke Patients and methods: Prospective control study of 67 patients admitted to hospital with ischemic stroke envaulted by D-dimer assay at admission and evaluate for prognostic value of D- dimer in Versus with 69 healthy control individuals. Results and discussion: In this study There is significant difference between D-dimer level between patients with ischemic stroke and control group with P value 0.0001Our findings were consistent with results of previous prospective studies showing that D-dimer levels were elevated in the acute phase of AIS compared with the healthy control population The results of this study suggest that there is no significant correlation between levels of D-dimer and the presence of complications, venous thrombosis, or mortality. Additionally, the study found a weak correlation between D-dimer levels and the occluded artery or the volume of infarction, with non-significant P values in both ANOVA and ETA analyses. However, D-dimer levels were found to be higher in cases of middle cerebral artery occlusion compared to occlusion of smaller vessels. Another study conducted by Anna Ramos et al found that higher levels of D-dimer were independently associated with large vessel occlusion (LVO), even after adjusting for other biomarkers and clinical covariates. This association may be due to the composition and quantity of the thrombus, as larger and fibrin-rich thrombi tend to result in a greater increase in D-dimer levels. Higher D-dimer levels have also been observed in patients with larger pulmonary or deep vein thrombosis in previous studies. Conclusion Is this study we conclude close relationship between the ischemic stroke and D-dimer but no clear association with complications during hospitalization and volume and type of blood vessel involved of stroke and we need large sample and 30 days follow to assess their correlation